Endocytosis: EH domains lend a hand

Endocytosis: EH domains lend a hand

A number of proteins that have been implicated in endocytosis feature a conserved protein-interaction module known as an EH domain. The three-dimensional structure of an EH domain has recently been solved, and is likely to presage significant advances in understanding molecular mechanisms of endocytosis.

Did cortical remapping lend artist a hand?

This study was possible thanks to a large number of photographers documenting the common guillemots of Stora Karlsö in present and historical times. See Supplemental experimental procedures for a list of all photographers that have kindly contributed to this project. In addition, Aron Hejdström, Rolf Jacobson, Gotlands Museum and Vänersborgs Museum provided photographical material and contacts....

9/11 New York City: Canadians lend a hand.

Finger creases lend a hand in Kabuki syndrome.

Kabuki syndrome (KS) is a rare syndrome associating malformations with intellectual deficiency and numerous visceral, orthopedic, endocrinological, immune and autoimmune complications. The early establishment of a diagnostic of KS leads to better care of the patients and therefore prevents complications such as perception deafness, severe complications of auto-immune diseases or obesity. Howeve...

A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis.

Sequencing of the entire genome of S. cerevisiae has revealed the existence of five proteins containing EH domains. These are protein-protein interaction modules first described in mammalian Eps15, a protein that is involved in clathrin-dependent endocytosis. Two of the yeast proteins, End3p and Pan1p, are required for the internalization step of endocytosis. We report characterization of the n...